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JAMA Ophthalmology Clinical Challenge
September 19, 2019

Middle-aged Man With Foveal Photoreceptor Loss

Author Affiliations
  • 1Department of Ophthalmology, Hospital San Raffaele, University Vita Salute San Raffaele, Milan, Italy
JAMA Ophthalmol. Published online September 19, 2019. doi:10.1001/jamaophthalmol.2019.3643

A 38-year-old man was referred to the medical retina service for evaluation of bilateral macular lesions noted by his general ophthalmologist. Medical history was otherwise unremarkable. On examination, his best-corrected visual acuity was 20/20 OU, although his vision was slightly eccentric. His pupils were round and reactive. The slitlamp examination of the anterior segment was unremarkable. Dilated fundus examination revealed subtle bilateral yellow foveal spots. Optical coherence tomography (OCT) displayed the presence of a bilateral foveal defect of the external limiting membrane and ellipsoid zone bands (Figure).

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