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Comment & Response
September 19, 2019

Calcium, Diet, Imaging, and Age-Related Macular Degeneration

Author Affiliations
  • 1Department of Ophthalmology and Visual Sciences, EyeSight Foundation of Alabama Vision Research Laboratories, School of Medicine, University of Alabama at Birmingham
  • 2Singapore National Eye Center, Singapore Eye Research Institute, Singapore
  • 3Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom
JAMA Ophthalmol. 2019;137(11):1333-1334. doi:10.1001/jamaophthalmol.2019.2725

To the Editor Because nonneovascular age-related macular degeneration (AMD) is prevalent and treatment options are limited, hypotheses to support dietary modification are especially welcome. We congratulate Tisdale et al1 for demonstrating that higher levels of calcium intake from diet and supplements are associated with a reduced risk of progression to advanced AMD in a secondary data analysis of the Age-Related Eye Disease Study (n = 4751; 1992-2001). An accompanying Invited Commentary2 encourages mechanistic follow-up. Recent developments in imaging, molecular eye pathology, and cell biology together support the hypothesis that retinal calcium regulation plays a role in nonneovascular AMD.