To the Editor Because nonneovascular age-related macular degeneration (AMD) is prevalent and treatment options are limited, hypotheses to support dietary modification are especially welcome. We congratulate Tisdale et al1 for demonstrating that higher levels of calcium intake from diet and supplements are associated with a reduced risk of progression to advanced AMD in a secondary data analysis of the Age-Related Eye Disease Study (n = 4751; 1992-2001). An accompanying Invited Commentary2 encourages mechanistic follow-up. Recent developments in imaging, molecular eye pathology, and cell biology together support the hypothesis that retinal calcium regulation plays a role in nonneovascular AMD.
Curcio CA, Tan ACS, Lengyel I. Calcium, Diet, Imaging, and Age-Related Macular Degeneration. JAMA Ophthalmol. 2019;137(11):1333–1334. doi:https://doi.org/10.1001/jamaophthalmol.2019.2725
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