To the Editor Using ultra-widefield fluorescein angiography, Nicholson and colleagues1 sought to establish whether a specific quantity of retinal capillary nonperfusion (RCNP) is associated with the development of proliferative diabetic retinopathy. However, their research strategy and principal conclusion (ie, that the threshold area of RCNP required for proliferative diabetic retinopathy induction is 118.3 disc areas) rest on arguably unwarranted assumptions.
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McLeod D. Nonperfused Inner Retina May Be Anoxic, Hypoxic, or Normoxic. JAMA Ophthalmol. 2019;137(11):1333. doi:10.1001/jamaophthalmol.2019.3588
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