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Ophthalmic Images
October 10, 2019

Thyroid Glandular Epithelial Choristoma of the Iris

Author Affiliations
  • 1Department of Ophthalmology Rizaiye Mah, Elazig Training and Research Hospital, Merkez Elazig, Turkey
  • 2Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor
JAMA Ophthalmol. 2019;137(10):e186228. doi:10.1001/jamaophthalmol.2018.6228

A healthy 76-year-old man presented with a right iris mass that had been present since birth but had recently enlarged. His visual acuity was 20/60 OD and 20/20 OS. Slitlamp biomicroscopy results showed a peripapillary yellow-white iris lesion with multiple overlying cystoid abnormalities and intrinsic vessels at the 6 o’clock position measuring 4 × 3 × 1.7 mm (Figure, A). Ultrasound biomicroscopy results showed solid and highly reflective cystoid components of the lesion. There was no anterior chamber angle or ciliary body involvement. The patient underwent iridectomy. Histopathology results showed glandular tissue with follicles containing colloid, fibrosis, and calcification, which were consistent with thyroid glandular epithelial choristoma (Figure, B). Immunohistochemistry results were positive for nuclear thyroid transcription factor-1, cytoplasmic cytokeratin, and cytoplasmic and follicular thyroglobulin. Staining results were negative for calcitonin and chromogranin A. After 1-year follow-up, no recurrence or systemic problem was observed. Choristomas rarely involve the iris, the most common being lacrimal gland choristomas.1-5