A 17-month-old girl with group B retinoblastoma in her right eye developed recurrence of a parafoveal tumor (Figure, A) after 6 cycles of intravenous chemotherapy. Despite treatment with indocyanine green–enhanced transpupillary thermotherapy, optical coherence tomography (vertical orientation) demonstrated continued tumor growth toward the foveola. The patient was subsequently treated with 2 cycles of intra-arterial chemotherapy, after which complete tumor regression to a flat scar was documented clinically and by optical coherence tomography (vertical orientation) (Figure, B). The foveola remained intact. Optical coherence tomography may be a helpful tool in the documentation of retinoblastoma response, particularly in patients with small tumors.1-3
Yu MD, Dalvin LA, Shields CL. Optical Coherence Tomography Monitoring in a Patient With Retinoblastoma. JAMA Ophthalmol. 2019;137(11):e186243. doi:10.1001/jamaophthalmol.2018.6243
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.