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Ophthalmic Images
November 14, 2019

Optical Coherence Tomography Monitoring in a Patient With Retinoblastoma

Author Affiliations
  • 1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
  • 2Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota
JAMA Ophthalmol. 2019;137(11):e186243. doi:10.1001/jamaophthalmol.2018.6243

A 17-month-old girl with group B retinoblastoma in her right eye developed recurrence of a parafoveal tumor (Figure, A) after 6 cycles of intravenous chemotherapy. Despite treatment with indocyanine green–enhanced transpupillary thermotherapy, optical coherence tomography (vertical orientation) demonstrated continued tumor growth toward the foveola. The patient was subsequently treated with 2 cycles of intra-arterial chemotherapy, after which complete tumor regression to a flat scar was documented clinically and by optical coherence tomography (vertical orientation) (Figure, B). The foveola remained intact. Optical coherence tomography may be a helpful tool in the documentation of retinoblastoma response, particularly in patients with small tumors.1-3

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