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Invited Commentary
December 5, 2019

Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation

Author Affiliations
  • 1Stein Eye Institute, University of California–Los Angeles School of Medicine, Los Angeles
  • 2Doheny Eye Institute, University of California–Los Angeles School of Medicine, Los Angeles
JAMA Ophthalmol. 2020;138(2):126-127. doi:10.1001/jamaophthalmol.2019.5099

The advent of optical coherence tomography angiography (OCTA), a relatively new tool to image the retinal and choroidal microvasculature with depth-resolved capability, has been met with great excitement by some ophthalmologists. This noninvasive technology is a potentially valuable instrument to differentiate flow impairment in the superficial vs deep retinal capillary plexus, and it can quantify nonperfusion in eyes with retinal vascular disease. Moreover, OCTA has advanced understanding of the microvascular morphology of choroidal neovascularization and has demonstrated its various growth patterns.1,2 It also has highlighted the potential importance of inner choroidal flow impairments associated with the development and progression of various macular diseases, including placoid-associated disorders (eg, acute posterior multifocal placoid pigment epitheliopathy) and age-related macular degeneration, and has provided a quantitative tool to measure inner choroidal flow impairment.3,4

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