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JAMA Ophthalmology Clinical Challenge
January 23, 2020

Retinal Pigment Abnormalities in a Woman With Diabetes

Author Affiliations
  • 1Medical student, Emory University School of Medicine, Atlanta, Georgia
  • 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia
JAMA Ophthalmol. 2020;138(3):316-317. doi:10.1001/jamaophthalmol.2019.4992

A 49-year-old woman presented for evaluation of abnormal retinal pigmentation and concern for cancer-associated retinopathy. The patient reported having difficulty with night driving owing to glare. She reported no other ocular history. The patient’s medical history was significant for type 2 diabetes diagnosed in her 30s and managed with metformin therapy, hypertension, mild hearing loss, and thyroid cancer that was in remission following thyroidectomy and radiotherapy. The patient had been told that radioactive iodine therapy damaged her pancreas and predisposed her to diabetes. The patient denied exposure to retinotoxic drugs.

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