A 5-year-old girl presented with a disfiguring right eye conjunctival lesion that first developed at age 4 months and recurred despite multiple excisions. The mother had perinatal condyloma acuminata. Because of long-standing astigmatism and visual occlusion by the exuberant papilliform masses (Figure, A), the eye was amblyopic with 20/80 best-corrected visual acuity.
No-touch excision and cryotherapy were conducted. The biopsy results showed a fibrovascular core, acanthotic nonkeratinized squamous epithelium with intact basement membrane, and koilocytosis. Polymerase chain reaction results identified human papillomavirus type 6, consistent with conjunctival squamous papilloma. Postoperatively, topical interferon α-2b was administered for 3 months. There were no recurrences after 4 years (Figure, B) and her visual acuity recovered to 20/30 with amblyopia treatment.
Eldeeb M, Hegazy O, Chan EW. Successful Treatment of Exuberant Conjunctival Squamous Papilloma. JAMA Ophthalmol. 2020;138(2):e190930. doi:10.1001/jamaophthalmol.2019.0930
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