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Invited Commentary
February 20, 2020

Visual Acuity Outcome at Age 10.5 Years for Treatment of Monocular Infantile Cataract—It Is Worth the Effort

Author Affiliations
  • 1Johns Hopkins University School of Medicine, Wilmer Eye Institute, Baltimore, Maryland
JAMA Ophthalmol. 2020;138(4):372-373. doi:10.1001/jamaophthalmol.2020.0018

Congratulations to the 114 families and the Infant Aphakia Treatment Study (IATS) group for completion of a 10-year study of surgery for infantile monocular cataract with a remarkable 96% follow-up for the primary outcome.1 As reported in this issue of JAMA Ophthalmology, IATS was a multicenter randomized clinical trial of initial surgery for monocular cataract for infants aged 1 to 6 months comparing primary intraocular lens (IOL) implantation with immediate contact lens correction, thereafter treated with best individualized clinical care.1 The infants enrolled were selected if the eye with the cataract had no additional ocular problems, such as persistent fetal vasculature, their fellow eye was normal, and there were no other medical problems that would be expected to cause difficulty with determining quantitative visual acuity. Postoperative clinical care was supported by the study group emphasizing follow-up and encouraging amblyopia treatment. Together, these eligibility criteria and follow-up care should produce the best-case outcomes for both surgical approaches.

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