An elderly patient presented with a corneal ulcer with underlying infiltrate and hypopyon secondary to Pseudomonas aeruginosa. The patient initiated treatment with ciprofloxacin, 0.3%, ophthalmic solution and returned after 2 days with substantial white corneal deposits (Figure, A). At a 2-week follow-up, the infiltrate and hypopyon had improved, but the deposits remained. The patient was switched to moxifloxacin, 0.5%, ophthalmic solution, and on follow-up 1 week later, complete dissipation of the deposits was noted, with residual underlying fibrosis and neovascularization into the cornea (Figure, B).
Quan AV, Huang AM, Galor A. Ciprofloxacin Corneal Deposits With Complete Dissipation After Switching to Moxifloxacin. JAMA Ophthalmol. 2020;138(3):e190921. doi:10.1001/jamaophthalmol.2019.0921
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