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Ophthalmic Images
March 12, 2020

Ciprofloxacin Corneal Deposits With Complete Dissipation After Switching to Moxifloxacin

Author Affiliations
  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • 2University of Central Florida College of Medicine, Orlando
JAMA Ophthalmol. 2020;138(3):e190921. doi:10.1001/jamaophthalmol.2019.0921

An elderly patient presented with a corneal ulcer with underlying infiltrate and hypopyon secondary to Pseudomonas aeruginosa. The patient initiated treatment with ciprofloxacin, 0.3%, ophthalmic solution and returned after 2 days with substantial white corneal deposits (Figure, A). At a 2-week follow-up, the infiltrate and hypopyon had improved, but the deposits remained. The patient was switched to moxifloxacin, 0.5%, ophthalmic solution, and on follow-up 1 week later, complete dissipation of the deposits was noted, with residual underlying fibrosis and neovascularization into the cornea (Figure, B).

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