Frequentist Analysis of Death Associated With Intravitreal Anti–Vascular Endothelial Growth Factor Therapy

To the Editor We present some complementary frequentist meta-analysis to an article published.¹ The authors only used articles published in the English language. Although with the Peters and Egger test, they did not find a publication bias (P = .44; P = .19), when analyzing the funnel plot graph, an asymmetry is evidenced. This may reflect a selection bias by language; there is a lack of small articles that should have a result in the direction of a higher risk of mortality, so the presence of this bias may favor statistical nonsignificance and must be taken into account when interpreting the results.