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Comment & Response
March 12, 2020

Frequentist Analysis of Death Associated With Intravitreal Anti–Vascular Endothelial Growth Factor Therapy

Author Affiliations
  • 1Fundación Oftalmológica 2020, Iberoamerican Cochrane Network, Santiago, Chile
  • 2Andrés Bello University, School of Nursing, Santiago, Chile
JAMA Ophthalmol. Published online March 12, 2020. doi:10.1001/jamaophthalmol.2020.0286

To the Editor We present some complementary frequentist meta-analysis to an article published.1 The authors only used articles published in the English language. Although with the Peters and Egger test, they did not find a publication bias (P = .44; P = .19), when analyzing the funnel plot graph, an asymmetry is evidenced. This may reflect a selection bias by language; there is a lack of small articles that should have a result in the direction of a higher risk of mortality, so the presence of this bias may favor statistical nonsignificance and must be taken into account when interpreting the results.

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