To the Editor We present some complementary frequentist meta-analysis to an article published.1 The authors only used articles published in the English language. Although with the Peters and Egger test, they did not find a publication bias (P = .44; P = .19), when analyzing the funnel plot graph, an asymmetry is evidenced. This may reflect a selection bias by language; there is a lack of small articles that should have a result in the direction of a higher risk of mortality, so the presence of this bias may favor statistical nonsignificance and must be taken into account when interpreting the results.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Fau C, Nabzo S, Nasabun V. Frequentist Analysis of Death Associated With Intravitreal Anti–Vascular Endothelial Growth Factor Therapy. JAMA Ophthalmol. 2020;138(5):586. doi:10.1001/jamaophthalmol.2020.0286
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: