In the report in this issue of JAMA Ophthalmology by Lam et al1 on the application of virtual reality (VR) simulation of daily activities to evaluate vision-associated disability in patients with moderate to severe glaucoma, authors asked a simple yet very important clinical question: can real-world visual performance be estimated with VR simulations to inform clinicians about the patient’s vision-associated disability? In other words, can we visualize the levels of disability that patients are experiencing? In this study, they designed 5 interactive VR environments that included supermarket shopping and stair and city navigations in daytime and nighttime to simulate the daily activities in a local community and tested them on patients with glaucoma and healthy individuals.