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Ophthalmic Images
April 9, 2020

Resolution of Nystagmus Following Treatment for Retinoblastoma

Author Affiliations
  • 1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
JAMA Ophthalmol. 2020;138(4):e190382. doi:10.1001/jamaophthalmol.2019.0382

An 11-month-old girl with bilateral retinoblastoma presented with leukocoria and continuous nystagmus in both eyes (Figure). Her visual acuity was no fix or follow. She was treated with intravenous chemotherapy (6 sessions) and subconjunctival carboplatin in both eyes, as well as tumor consolidation with cryotherapy and transpupillary thermotherapy. Fundus photography, ultrasonography, and nystagmus assessment with video documentation were performed at each visit. This treatment led to a complete regression of retinoblastoma in both eyes, and the nystagmus resolved after 2 sessions of intravenous chemotherapy. Her visual acuity at the final visit was 20/100 OD and 20/200 OS. Prior to treatment, there had been no decrease in nystagmus (Video).

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