Rhegmatogenous retinal detachment (RRD) happens when a vitreous humor–filled gap forms between the neurosensory and the retinal pigment epithelium layers. Although the condition is relatively infrequent and has surgical repair success rates greater than 80%,1 the visual acuity outcomes are poor in half of cases, especially patients who present with a detached macula.2 Male sex, myopia, and cataract surgery are all risk factors disproportionally overrepresented among patients with RRD. Because of the difficulty assembling sufficiently well-powered prospective studies, which is particularly intense for low-frequency disorders such as RRD, quantifying how much risk is associated with the presence of each factor and establishing the nature of their association with retinal detachment remains elusive.
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Hysi PG, Simcoe MJ. Rhegmatogenous Retinal Detachment in the Age of Genomic Medicine. JAMA Ophthalmol. Published online April 30, 2020. doi:10.1001/jamaophthalmol.2020.1240
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