[Skip to Navigation]
Original Investigation
May 14, 2020

Association of Co-occurring Dementia and Self-reported Visual Impairment With Activity Limitations in Older Adults

Author Affiliations
  • 1University of Michigan Medical School, Ann Arbor
  • 2Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • 3John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City
  • 4Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 5Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
  • 6Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor
  • 7Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor
JAMA Ophthalmol. 2020;138(7):756-763. doi:10.1001/jamaophthalmol.2020.1562
Key Points

Question  What is the association of co-occurring dementia and self-reported visual impairment on activity limitations in older US adults?

Findings  In this nationally representative study, participants with dementia and self-reported visual impairment reported greater limitations in mobility, self-care, and household activities than would be expected based on the individual associations of each of these health conditions.

Meaning  In this analysis, activity limitations were more severe in older adults with coexisting dementia and self-reported visual impairment; if causal associations are established, interventions may be warranted across the activity spectrum to address the growing burden of visual impairment and dementia in an aging population


Importance  The number of older adults with visual impairment (VI) and dementia is projected to increase in the US because of the aging of the population. Dementia and VI commonly co-occur and are each independently associated with disability. To care for an aging population, it may be important to characterize the association of coexisting dementia and self-reported VI on daily functioning.

Objective  To evaluate the association of co-occurring dementia and self-reported VI on daily functioning.

Design, Setting, and Participants  This cross-sectional analysis of a nationally representative cohort study used data from the National Health and Aging Trends Study (NHATS), an annual study of US adults 65 years and older. Participants in the 2015 survey with complete data on outcomes, associated factors, and covariates were included in this study. Data analysis took place from January 2019 to November 2019.

Main Outcomes and Measures  Multivariable Poisson regression was used to model the independent associations and interaction of dementia and self-reported VI status on 3 functional activity scales (self-care, mobility, and household activities). Marginal predicted proportions were calculated. Analyses were adjusted for sociodemographic and medical factors and accounted for the complex survey design.

Results  A total of 7124 participants were included. The weighted proportion of female respondents was 55.3% (95% CI, 54.0%-56.6%), and 56.1% (95% CI, 54.1%-58.1%) were between 65 and 74 years old. Self-reported VI was present in 8.6% (95% CI, 7.8%-9.3%) of participants, while 8.3% (95% CI, 7.8%-8.9%) had possible dementia and 6.3% (95% CI, 5.7%-6.9%) had probable dementia. Self-reported VI was associated with an expected decrease in mobility score of 14.7% (functional scale scores: no VI, 10.82 vs VI, 9.23), self-care score of 9.5% (no VI, 14.54 vs VI, 13.16), and household activity score of 15.2% (no VI, 18.23 vs VI, 15.45), while probable dementia was associated with expected decreases of 27.8% (no dementia, 10.82 vs probable dementia, 7.81), 22.9% (no dementia, 14.54 vs probable dementia, 11.20), and 34.7% (no dementia, 18.23 vs probable dementia, 11.90), respectively. Among those with probable dementia and self-reported VI, there was an expected decrease in mobility score of 50.1% (functional ability scores: no VI and no dementia, 10.82 vs VI and probable dementia, 5.40), self-care score of 42.4% (no VI and no dementia, 14.54 vs VI and probable dementia, 8.38), and household activity score of 52.4% (no VI and no dementia, 18.23 vs VI and probable dementia, 8.68), suggesting that respondents with co-occurring dementia and self-reported VI had lower functional activity scores than would be associated with the independent contributions of these conditions.

Conclusions and Relevance  Older adults with both dementia and self-reported VI may be at high risk for disability, and their co-occurrence may potentiate this risk. These findings suggest that the growing population of older adults with both visual impairment and dementia may benefit from interventions to maximize vision and cognition and promote functioning and independence.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words