[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.204.176.125. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 154
Citations 0
Comment & Response
May 21, 2020

Stratification Clarification for Methods for Randomized Clinical Trials

Author Affiliations
  • 1F. I. Proctor Foundation, University of California, San Francisco, San Francisco
  • 2Department of Ophthalmology, University of California, San Francisco, San Francisco
  • 3Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco
JAMA Ophthalmol. Published online May 21, 2020. doi:10.1001/jamaophthalmol.2020.1551

To the Editor We applaud the cautionary warnings of Douglas A. Jabs, MD, MBA, regarding subgroup analyses in an Invited Commentary1 in JAMA Ophthalmology on our recent article2 in JAMA. The presentation of our trial findings reflected just such a perspective—even for the case of posterior uveitis or panuveitis, the principal prespecified subgroup that accounted for most of the included patients.2 However, we believe readers may be misled on an important point: the Invited Commentary states that randomization was lost because enrollment was not stratified by anatomic subgroup.1

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    ×