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Comment & Response
May 21, 2020

Stratification Clarification for Methods for Randomized Clinical Trials

Author Affiliations
  • 1F. I. Proctor Foundation, University of California, San Francisco, San Francisco
  • 2Department of Ophthalmology, University of California, San Francisco, San Francisco
  • 3Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco
JAMA Ophthalmol. Published online May 21, 2020. doi:10.1001/jamaophthalmol.2020.1551

To the Editor We applaud the cautionary warnings of Douglas A. Jabs, MD, MBA, regarding subgroup analyses in an Invited Commentary1 in JAMA Ophthalmology on our recent article2 in JAMA. The presentation of our trial findings reflected just such a perspective—even for the case of posterior uveitis or panuveitis, the principal prespecified subgroup that accounted for most of the included patients.2 However, we believe readers may be misled on an important point: the Invited Commentary states that randomization was lost because enrollment was not stratified by anatomic subgroup.1

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