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Invited Commentary
June 25, 2020

Optical Coherence Tomography Angiography as an Important Diagnostic Tool for Amblyopia

Author Affiliations
  • 1Fundus Image Reading Centre, National Healthcare Group Eye Institute, Singapore
  • 2National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore
JAMA Ophthalmol. Published online June 25, 2020. doi:10.1001/jamaophthalmol.2020.2219

Amblyopia has been a diagnosis of exclusion. Besides best-corrected visual acuity, there are presently no standardized metrics that are used for the diagnosis and evaluation of amblyopia. For more than a decade, studies using structural optical coherence tomography (OCT) had identified several differences between amblyopic and control eyes.1 Qualitatively, the increase in height of the ellipsoid zone at the central fovea was noted to be attenuated or absent in 60% of amblyopic eyes compared with 29% of normal eyes.2 Several studies had reported that the foveal minimum thickness was greater in amblyopic eyes compared with normal controls, but the differences were small.2,3 Differences had also been reported in choroidal and retinal nerve fiber layer thicknesses, whereas other studies had reported no substantial differences between amblyopic and control eyes.1,3

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