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September 10, 2020

Presumed Chloroquine Retinopathy With Short-term Therapy for Glioblastoma Multiforme

Author Affiliations
  • 1Department of Ophthalmology, Columbia University Irving Medical Center, New York, New York
  • 2Jonas Children’s Vision Care, New York, New York
  • 3Renaissance School of Medicine at Stony Brook University, Stony Brook, New York
  • 4Weill Cornell Medical College, New York, New York
  • 5State University of New York at Downstate Medical Center, Brooklyn
  • 6Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York
  • 7Harkness Eye Institute, Columbia University Medical Center, New York, New York
JAMA Ophthalmol. 2020;138(11):1215-1217. doi:10.1001/jamaophthalmol.2020.3251

Chloroquine and its analogue, hydroxychloroquine, are well-known antimalarial medications that are commonly used to treat systemic lupus erythematosus, rheumatoid arthritis, and various other autoimmune conditions.1 Recently, chloroquine has been used as an adjunct therapy in the treatment of several aggressive cancers, including glioblastoma multiforme.2 An important adverse effect of long-term chloroquine or hydroxychloroquine therapy is substantial and irreversible visual acuity loss accompanied by night blindness, which consequently necessitates careful ophthalmologic screening to prevent drug toxicity and retinal damage.1 In this report, we describe a case of acute-onset visual field loss in a 31-year-old woman treated with high-dose chloroquine therapy for glioblastoma multiforme.

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