Chloroquine and its analogue, hydroxychloroquine, are well-known antimalarial medications that are commonly used to treat systemic lupus erythematosus, rheumatoid arthritis, and various other autoimmune conditions.1 Recently, chloroquine has been used as an adjunct therapy in the treatment of several aggressive cancers, including glioblastoma multiforme.2 An important adverse effect of long-term chloroquine or hydroxychloroquine therapy is substantial and irreversible visual acuity loss accompanied by night blindness, which consequently necessitates careful ophthalmologic screening to prevent drug toxicity and retinal damage.1 In this report, we describe a case of acute-onset visual field loss in a 31-year-old woman treated with high-dose chloroquine therapy for glioblastoma multiforme.
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Nuzbrokh Y, Jauregui R, Oh JK, Moazami G, Sparrow JR, Tsang SH. Presumed Chloroquine Retinopathy With Short-term Therapy for Glioblastoma Multiforme. JAMA Ophthalmol. 2020;138(11):1215–1217. doi:10.1001/jamaophthalmol.2020.3251
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