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Invited Commentary
October 15, 2020

Pediatric Optic Neuritis—Building Foundations for a Randomized Clinical Trial

Author Affiliations
  • 1Singapore National Eye Centre, Singapore
  • 2Singapore Eye Research Institute, Singapore
  • 3Duke-NUS Medical School, Singapore
JAMA Ophthalmol. 2020;138(12):1262-1263. doi:10.1001/jamaophthalmol.2020.4250

Optic neuritis is a well-studied condition in adults.1 It remains a rare and poorly understood disease in children, with limited information on causation, natural history, visual outcomes, associated neurological diseases, response to treatment, and prognosis. This is similar to the delay in the initial description of pediatric multiple sclerosis by Pierre Marie, MD, in 1893, occurring 15 years after the description of multiple sclerosis in adults by Jean-Martin Charcot, MD. Current concepts in pediatric optic neuritis (PON) are sometimes ambiguous or even conflicting, because published studies have generally been small and retrospective.2 In response to this important need to better understand PON, an alliance between the Pediatric Eye Disease Investigator Group and the Neuro-Ophthalmology Research Disease Investigator Consortium planned an ambitious, prospective pilot observational study of PON.3

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