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Ophthalmic Images
December 10, 2020

Iris Metastasis Regression Following Osimertinib Treatment

Author Affiliations
  • 1Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • 2College of Medicine, Chang Gung University, Taoyuan, Taiwan
  • 3Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
JAMA Ophthalmol. 2020;138(12):e202095. doi:10.1001/jamaophthalmol.2020.2095

A 75-year-old woman presented with a pinkish lesion in her right iris. She had been diagnosed with lung adenocarcinoma with an epidermal growth factor receptor T790M (c.2369C>T) sequence variation in exon 20 and undergone thoracoscopic lobectomy 7 years earlier. Her visual acuity was not affected, and her intraocular pressure level was normal. A slitlamp biomicroscopic examination showed a localized lesion extending from 5 o’clock to 8 o’clock in the right iris (Figure, A). Whole-body computed tomography revealed focal lung cancer recurrence with local and distant lymph node metastases. After she received treatment with osimertinib (a third-generation epidermal growth factor receptor inhibitor) for 3 months, the iris tumor completely regressed (Figure, B). During 15 months of follow-up, there was no recurrence of lung cancer or iris metastasis. She continues to receive osimertinib up to the present.

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