A 61-year-old White man was referred for evaluation of a suspected iris lesion in the right eye. His visual acuity was 20/20 OD and 20/25 OS. A slitlamp examination of the left eye had unremarkable results. A slitlamp examination of the right eye revealed forward iris bowing and a barely visualized pigmented mass arising from the posterior iris surface at the pupillary margin temporally (Figure, A). Anterior segment swept-source optical coherence tomography revealed a large cyst of the iris pigment epithelium, measuring 3.0 mm in basal dimension and 1.8 mm in thickness. There was no central hyperreflectivity (Figure, B). Because of the absence of symptoms and a presumed diagnosis of an iris pigment epithelium cyst, observation was advised.