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Ophthalmic Images
January 20, 2021

Spontaneous Regression of Presumed Ocular Surface Squamous Neoplasia

Author Affiliations
  • 1Ocular Oncology Service, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • 2Ocular Oncology Service, Saint Bartholomew's Hospital, West Smithfield, London, United Kingdom
  • 3UCL Institute of Ophthalmology, London, United Kingdom
JAMA Ophthalmol. 2021;139(1):e204149. doi:10.1001/jamaophthalmol.2020.4149

A 76-year old woman presented with an increasingly gelatinous lesion located on the nasal conjunctiva of the left eye (Figure, A), which had originally been discovered 6 months before as a white spot. She had no relevant ocular or medical history. A clinical diagnosis of ocular surface squamous neoplasia was made, and she was listed for an excisional biopsy with cryotherapy. No topical or systemic medication was commenced. The patient returned to the clinic before the planned surgery (35 days after the first visit), and it was noted then that the lesion had disappeared spontaneously (Figure, B), before histopathologic confirmation of the clinical diagnosis of ocular surface squamous neoplasia was made.

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