Anti–vascular endothelial growth factor (VEGF) therapy has revolutionized the treatment of diabetic retinopathy, including diabetic macular edema and proliferative diabetic retinopathy (PDR). Diabetic Retinopathy Clinical Research (DRCR) Retina Network Protocol S1 and the Clinical Efficacy of Intravitreal Aflibercept Versus Panretinal Photocoagulation for Best Corrected Visual Acuity in Patients With Proliferative Diabetic Retinopathy at 52 Weeks (CLARITY)2 trials demonstrated superior visual acuity outcomes with anti-VEGF treatment compared with panretinal photocoagulation (PRP). DRCR Retina Network Protocol T showed that visual acuity improved in anti-VEGF–treated eyes with center-involved diabetic macular edema (CI-DME) accompanied by vision loss.3 However, the role of prophylactic anti-VEGF treatment in eyes with moderate or severe nonproliferative diabetic retinopathy (NPDR) and good vision to reduce the risk of progression to PDR or CI-DME with vision loss has not been defined. DRCR Retina Network Protocol W addresses this question.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Apte RS, Hwang CK. Practicality of Prophylactic Aflibercept to Reduce Diabetic Retinopathy Progression. JAMA Ophthalmol. 2021;139(7):713–714. doi:10.1001/jamaophthalmol.2021.0624
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.