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JAMA Ophthalmology Clinical Challenge
April 1, 2021

Salt-and-Pepper Retinopathy in a Woman With Hearing Loss

Author Affiliations
  • 1Emory University School of Medicine, Atlanta, Georgia
  • 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia
JAMA Ophthalmol. Published online April 1, 2021. doi:10.1001/jamaophthalmol.2020.4624

A 58-year-old woman with interstitial cystitis presented for pentosan polysulfate (Elmiron) maculopathy screening. She reported no visual symptoms or ocular history, and routine eye examination results 6 months prior were reportedly normal. She was diagnosed with interstitial cystitis in 2004 and had been taking pentosan polysulfate, 100 mg twice daily, for 4½ years for a cumulative dose of 324 g. Her medical history was otherwise significant for moderate bilateral hearing loss detected in early childhood and type 2 diabetes, hyperlipidemia, and hypothyroidism treated with a therapeutic regimen of metformin, pravastatin, and levothyroxine supplementation, respectively.

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