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Invited Commentary
June 17, 2021

When the N Is 65 Million—The Rise of Database Research

Author Affiliations
  • 1Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas
  • 2The Eye Institute, Medical College of Wisconsin, Milwaukee
JAMA Ophthalmol. 2021;139(8):855-856. doi:10.1001/jamaophthalmol.2021.1853

Launched in 2014, the American Academy of Ophthalmology IRIS Registry (Intelligent Research in Sight) is a repository containing data for more than 65 million unique patients, making it the largest national clinical specialty data registry currently in existence.1 A database of this magnitude has tremendous potential to unveil longitudinal trends and outcomes that feed our understanding of ophthalmic diseases and treatments. Over the past 7 years, as participation in the IRIS Registry has steadily grown, insights have followed.

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