A 72-year-old woman presented with new-onset decreased vision in the right eye. Her ocular history included pseudoexfoliation syndrome and glaucomatous optic neuropathy in the right eye. Past ocular surgery included uncomplicated trabeculectomy in the right eye treated with mitomycin C (3 months prior) and no ocular surgery history in the left eye. Her medical history included pulmonary Mycobacterium avium infection secondary to hypogammaglobulinemia. Computed tomography scan 2 months prior exhibited reactivation and she started treatment with clarithromycin (1000 mg/d), ethambutol (15 mg/kg/d), and rifabutin (300 mg/d).