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Invited Commentary
March 10, 2022

How Depression Might Relate to Dry Eye Disease

Author Affiliations
  • 1Miami Veterans Affairs Medical Center, Miami, Florida
  • 2Bascom Palmer Eye Institute, University of Miami, Miami, Florida
JAMA Ophthalmol. 2022;140(4):399-400. doi:10.1001/jamaophthalmol.2022.0146

In a secondary analysis of the DREAM study, Zhou et al1 examined associations between depression and dry eye severity, focusing on both clinical (symptoms and signs) and subclinical parameters (inflammatory markers in tears and on the ocular surface). The main conclusion of their work is that, similar to what previous studies found, individuals with depression (defined as scoring ≤42 on the Mental Component Summary [MCS] of the 36-Item Short Form Health Survey) had more severe dry eye disease (DED) symptoms, but mostly similar signs, compared with those without depression. Similar findings have been noted across various populations, including those in South Florida,2 Korea,3 and China.4

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