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JAMA Ophthalmology Clinical Challenge
July 14, 2022

A White Retinal Lesion With Calcification in an 11-Year-Old Boy

Author Affiliations
  • 1Department of Ophthalmology and Visual Sciences, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
  • 2Department of Ophthalmology and Visual Sciences, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
JAMA Ophthalmol. Published online July 14, 2022. doi:10.1001/jamaophthalmol.2022.1649

An 11-year-old boy was referred to assess a retinal mass in the left eye found on his first routine ophthalmic evaluation. He reported no present or past ocular symptoms and had negative findings on a review of systems. His history included full-term birth by cesarean delivery from an uncomplicated pregnancy. He had healthy, nonconsanguineous parents.

The ocular examination showed a visual acuity of 20/20 OU with no anterior segment abnormalities. Findings of dilated fundus examination of the right eye were within normal limits. In the left eye, a white, translucent solid lesion with calcification was noticeable in the inferonasal quadrant (Figure, A). The lesion measured approximately 1.6 mm in height, exhibited mild underlying chorioretinal changes, and had associated 3 vitreous seeds (Figure, A). There were no signs of internal vascularization or vitritis. Optical coherence tomography confirmed an intraretinal location and calcified deposits within the lesion (Figure, B).

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