The editorial by Bressler1 entitled "Evaluating New Retinal Imaging Techniques" stimulated us to consider the question of when it is appropriate to call for prospective and/or randomized clinical trials methodology early on in the development of diagnostic or therapeutic techniques. Our recent article2 prompted the editorial by Dr Bressler.
Freeman WR, Bartsch D, Mueller AJ, Banker AS. Innovation and Clinical Trials. Arch Ophthalmol. 1999;117(6):846. doi:https://doi.org/
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