Because the occurrence of anaphylactic or anaphylactoid reactions are so rare, we do not believe that these specific allergy tests have been done. After a thorough literature search, we could not find any references. However, these tests can be done. In fact, should such an allergic reaction occur after the simultaneous use of fluorescein and indocyanine green dye, it would be challenging to determine the precise cause. The specific concentration of fluorescein and indocyanine green in these skin tests would have to be determined. For the basics and principles of these allergy tests, we recommend the Manual of Allergy and Immunology Diagnosis and Therapy.1
Fritsche PL, Flipsen E. Evaluating New Retinal Imaging Techniques. Arch Ophthalmol. 1999;117(6):846–847. doi:https://doi.org/
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