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November 2000

Antirecoverin Antibodies and Autoimmune Retinopathy

Arch Ophthalmol. 2000;118(11):1577-1578. doi:10.1001/archopht.118.11.1577

RETINAL DEGENERATION is one of the leading causes of visual loss in the world. The mechanism of retinal cell death in different forms of retinal degenerations is not fully understood. There is evidence that a subset of patients with retinopathy may have an autoimmune component to the disease. Those patients with retinal disease possess circulating antibodies against retinal proteins. Based on clinical and experimental observations, it has been suggested that autoantibodies may participate in the development of acquired forms of retinopathies. Antiretinal antibodies are relatively specific for autoimmune retinopathy, in particular, in cancer-associated retinopathy (CAR) syndrome. The association of antibodies with retinal dysfunction has also been recognized in other forms of retinopathies, mainly those that resemble visual symptoms of CAR without underlying neoplasm or in idiopathic retinopathy with a history of abnormal electroretinogram results.1-4 Heterogeneity in recognition of retinal antigens has been detected in immunological tests using denatured proteins by immunoblotting analysis or by immunocytochemical analysis.

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