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April 2003

Lens Dislocation in Marfan Syndrome and UV-B Light Exposure

Arch Ophthalmol. 2003;121(4):585. doi:10.1001/archopht.121.4.585

Additional information that contributes to our Clinicopathologic Report1 has come to our attention. We described zonule-associated staining of matrix metalloproteinases (MMPs) in Marfan syndrome lens subluxation. We hypothesized that the product of the defective fibrillin-1 gene in Marfan syndrome is more prone to degradation by MMPs than normal fibrillin and that an imbalance of MMPs and their inhibitors could result in the progressive destruction of lens zonules and subsequent lens subluxation.

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