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September 2003

Controversy Regarding Pre-enucleation Radiation for Uveal Melanoma

Arch Ophthalmol. 2003;121(9):1346. doi:10.1001/archopht.121.9.1346

In their letter, Fine et al1 cite our work as an example of an incorrect conclusion based on an observational study, which the Collaborative Ocular Melanoma Study (COMS) has now corrected:"Observational data may be misleading, as illustrated by the findings of Char et al regarding pre-enucleation radiation therapy for large choroidal melanoma. These authors suggest that pre-enucleation radiation was harmful . . . ."