In the amblyopia treatment article by the Pediatric Eye Disease InvestigatorGroup (PEDIG),1 the authors state that they"conducted a randomized clinical trial to compare 2 hours vs 6 hours of dailypatching for moderate amblyopia" and subsequently reported no difference inthe therapeutic outcome. However, patient compliance for the prescribed numberof hours of occlusion was not well documented in this study. To determinethe effect of 1 treatment variable (number of hours of patching), anothervariable in the therapy (compliance with the prescribed number of patchinghours) cannot be left uncertain.
Bloom JN. The Effect of Patient Compliance on the Assessment of Amblyopia Treatment. Arch Ophthalmol. 2004;122(3):422. doi:10.1001/archopht.122.3.422-a
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