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April 2004

Toxic Effects of Intravitreal Indocyanine Green on Neuroretinal Cells

Arch Ophthalmol. 2004;122(4):663. doi:10.1001/archopht.122.4.663

We read with great interest the article by Paques et al1 aboutthe axon-tracing properties of indocyanine green (ICG). Although the authorsreported "no evidence of neural toxic effects" to the ganglion cells by observingthat "the ganglion cell layer had a normal appearance on histologic sectionsand by epifluorescence examination findings of flat-mounted slides,"1 these observations should be interpreted with cautionbecause of the 3 following reasons.