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April 2004

Toxic Effects of Intravitreal Indocyanine Green on Neuroretinal Cells—Reply

Arch Ophthalmol. 2004;122(4):664. doi:10.1001/archopht.122.4.664-a

In reply

We thank Dr Rodrigues and his colleagues for their interesting remarksabout our article.1 As they pointed out,the main goal of our study was to determine the cause of prolonged postoperativestaining of the disc after epiretinal application of ICG,2 whichis probably caused by the migration of ICG in axons of ganglion cells. Thus,our data about the toxic effect of ICG on retinal cells are limited by nature.We agree that a normal histological appearance at optical microscopy at agiven moment does not preclude other manifestations of toxicity such as functionalchanges, selective loss of cell subpopulations, and/or delayed cell death.Moreover, the presence of axonal diffusion raises concerns about the localeffects of ICG, especially when addressing long-term toxic effects.