William Stewart and the ISV-205 Study Group are to be congratulated on their innovative approach to preventing and perhaps treating steroid-induced glaucoma using topical diclofenac sodium.1 Could we seek a few clarifications?
What was the basis for selecting a sample size of 136 volunteers? What difference in intraocular pressure was predetermined to be clinically significant to arrive at this sample size?
Satav SS, Thomas R. Preventing Steroid-Induced Glaucoma. Arch Ophthalmol. 2005;123(7):1018. doi:10.1001/archopht.123.7.1018-a
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