I thank Drs Zetterberg and Zetterberg for their interest in my article. Interestingly, it was Darwin who first articulated the essential role of evolutionary reconfiguration. In his 1862 discussion of orchid evolution, he wrote that “When this or that part has been spoken of as contrived for some special purpose, it must not be supposed that it was originally always formed for this sole purpose. The regular course of events seems to be, that a part which originally served for one purpose, by slow changes becomes adapted for widely different purposes.”1
Brodsky MC. Evolution, Exaptation, and Stereopsis—Reply. Arch Ophthalmol. 2005;123(9):1281. doi:10.1001/archopht.123.9.1281-b
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