The retinal depression sign was first described in sickle cell retinopathy in 1978 by Goldbaum.1 It represents an area of focal retinal infarction that may occur not only in the retinopathy of sickling hemoglobinopathies, but also in other microvascular disorders such as diabetic2 and hypertensive3 retinopathies.
Shakoor A, Blair NP, Shahidi M. Imaging Retinal Depression Sign in Sickle Cell Anemia Using Optical Coherence Tomography and the Retinal Thickness Analyzer. Arch Ophthalmol. 2005;123(9):1278–1279. doi:10.1001/archopht.123.9.1278
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