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April 2006

Anti-inflammatory Fibrosis Suppression in Threatened Trabeculectomy Bleb Failure

Arch Ophthalmol. 2006;124(4):603. doi:10.1001/archopht.124.4.603

Systemic oral anti-inflammatory fibrosis suppression with prednisone, colchicine, and a nonsteroidal anti-inflammatory agent is effective in preventing fibrosis and bleb failure following threatened early trabeculectomy failure.1,2

A 75-year-old woman who had a limbal-based, Cairns-type trabeculectomy (without antimetabolites) for chronic angle-closure glaucoma and who showed signs of early impending bleb failure (increased vascularity, contraction of suture line, and elevated intraocular pressure) was seen by us on the fourth postoperative day.

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