Systemic oral anti-inflammatory fibrosis suppression with prednisone, colchicine, and a nonsteroidal anti-inflammatory agent is effective in preventing fibrosis and bleb failure following threatened early trabeculectomy failure.1,2
A 75-year-old woman who had a limbal-based, Cairns-type trabeculectomy (without antimetabolites) for chronic angle-closure glaucoma and who showed signs of early impending bleb failure (increased vascularity, contraction of suture line, and elevated intraocular pressure) was seen by us on the fourth postoperative day.
Ah-Chan JJ, Molteno ACB, Bevin TH. Anti-inflammatory Fibrosis Suppression in Threatened Trabeculectomy Bleb Failure. Arch Ophthalmol. 2006;124(4):603. doi:10.1001/archopht.124.4.603
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