In a recent editorial regarding the use of vitamin E for age-related macular degeneration, Chew and Clemons stated:
For these reasons, combined with little evidence from the meta-analysis of harm at the 400 IU/d dosage, we do not think there is increased risk of mortality associated with the AREDS [Age-Related Eye Disease Study] supplements that include 400 IU/d of vitamin E.1
Pulido JS. Heart Outcomes Prevention Evaluation–The Ongoing Outcomes Study, Vitamin E, and Age-Related Macular Degeneration. Arch Ophthalmol. 2006;124(11):1665. doi:10.1001/archopht.124.11.1665-a
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