Glaucoma is the second-leading cause of permanent blindness in developed nations.1 Of the many forms of glaucoma, primary open-angle glaucoma (POAG) is the most common. Primary open-angle glaucoma is a clinically defined condition that is actually a collection of distinct diseases that are all characterized by a progressive optic nerve degeneration associated with insidious loss of visual field. There is a significant genetic contribution to the pathogenesis of POAG, and several loci associated with POAG have been mapped (GLC1A, chromosome 1q24.3-q25.22; GLC1B, chromosome 2cent-q133; GLC1C, chromosome 3q21-244; GLC1D, chromosome 8q235; GLC1E, chromosome 10p15-p146; and GLC1F, chromosome 7q35-q367). Glaucoma genes have been identified at the GLC1A8 and GLC1E9 loci.
Fingert JH, Alward WLM, Kwon YH, et al. No Association Between Variations in the WDR36 Gene and Primary Open-Angle Glaucoma. Arch Ophthalmol. 2007;125(3):434–436. doi:10.1001/archopht.125.3.434-b
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