According to Greeff interstitial keratitis attacks persons below the age of forty, females more frequently than males. It usually depends upon hereditary syphilis and occasionally upon acquired. Next to syphilis the most frequent cause is tuberculosis, and rheumatic influences also may bring it about. There is doubtless some connection between interstitial keratitis and malaria, diabetes, influenza, and affections of female genital organs.
Reference: Herrnheiser. Arch Ophthalmol. 1897;26:625-626.