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April 1929


Arch Ophthalmol. 1929;1(4):468-474. doi:10.1001/archopht.1929.00810010486006

In 1924, von Szily1 reported experiments with herpes virus from herpetic keratitis, with which he produced uveitis in the eyes of rabbits, which was transmitted to the opposite eye, giving a clinical and histologic picture resembling sympathetic ophthalmia. In 1926, we2 reported experiments which confirmed his work, and gave added evidence that the process in these animals was one of extension in the nerves and chiasm to the opposite eye. Von Szily had advised inoculation of uveal tissue from eyes enucleated for sympathetic ophthalmia into a subscleral pouch in animals. We suggested that the chances were against the production of an involvement of the second eye by this method, as it succeeded with herpes virus in only 10 per cent of cases, and the occurrence of the involvement evidently depended on a number of circumstances. In the absence of ordinary bacteria, the production of uveitis in