The science of Galen prevailed until Andreas Vesaleus revealed by his dissection of the ocular tissue of man that the anterior humor of the eye did not resemble the white of an egg but was of a watery nature. Jacob Hovius (1702) some years later described the influx and efflux of this watery fluid in the anterior part of the eye. Since then a noteworthy amount of material has been written on the aqueous humor of man and animal, but a review of the literature discloses the fact that there is still little agreement as to the true nature and mode of formation of this intra-ocular fluid.
Several hypotheses have been presented to explain the mechanism of the formation of the aqueous humor. It is the consensus that the aqueous humor is derived from the circulating fluid—the blood and lymph—of the body. There is still some doubt as to
YUDKIN AM. THE AQUEOUS HUMORA CRITICAL REVIEW. Arch Ophthalmol. 1929;1(5):615–633. doi:10.1001/archopht.1929.00810010636011
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