The term heterochromia irides implies no more than a difference in color of the irides of an individual. However, after a superficial acquaintance with the facts, it becomes clear that difference in color produced in one iris by the action of iron or copper, or resulting from atrophy secondary to glaucoma or inflammation, is not part of the phenomenon which constitutes the "heterochromia problem." Heterochromia as such was popularized first by Fuchs, who reported a large series of cases. That his paper made physicians conscious of the problem is emphasized by the fact that complicated heterochromia is frequently called the "Fuchs type," though the phenomenon had been reported earlier. The first recorded observation was made by Lawrence, who in his treatise on "Diseases of the Eye," published in 1843, described two cases.
In 1869, Hutchinson reported three cases of heterochromia. In one, a patient, aged 26, had normal visual
HAESSLER FH. HETEROCHROMIA IRIDES. Arch Ophthalmol. 1929;2(3):333–347. doi:10.1001/archopht.1929.00810020347010
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