Since Hutchinson contributed his epoch-making observation in 1855 regarding interstitial keratitis and its relationship to congenital syphilis, there has been an abundance of reports, discussions and writings on the subject. In many ways little advance has been made in the knowledge of the condition. Especially is this true from the pathologic standpoint, since tissue from cases of interstitial keratitis in human beings is exceedingly difficult to obtain for microscopic study. Whatever increase in knowledge has been made is largely the result of experimental investigations on rabbits. It seems opportune, however, to review the literature for the past ten years on this subject, including both clinical and experimental observations.
Whether the corneal lesion is directly due to the presence in the cornea of the spirochetes or their endotoxins remains a matter for discussion. Two important articles have appeared, one by Igersheimer and the other by Löwenstein.
CLAPP CA. INTERSTITIAL KERATITIS: A REVIEW OF SOME OF THE IDEAS ADVANCED IN THE PAST DECADE. Arch Ophthalmol. 1929;2(5):580–587. doi:10.1001/archopht.1929.00810020601012
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: