From an ophthalmoscopic examination of what is commonly termed coloboma of the optic nerve, it is difficult to tell whether the developmental defect is in the optic nerve or in the adjacent choroid.
In a review of the literature, one encounters difficulty in classifying the cases, for there is wide latitude in many of the reports. Thus one finds the extremes—holes in the disk and extensive physiologic cup, to coloboma of the nerve head in association with coloboma of the choroid, ciliary body and iris. It is therefore impossible to tell accurately how many reports have been made, although one may have an idea from Crampton's1 review in 1912, when he collected twenty-one cases in sixteen patients, which report included the six unequivocal examples recorded by Coates,2 in all of which he had made histologic examinations. I found twenty-six additional cases (some very uncertain) with only
CALHOUN FP. BILATERAL COLOBOMA OF THE OPTIC NERVE: ASSOCIATED WITH HOLES IN THE DISK AND A CYST OF THE OPTIC SHEATH. Arch Ophthalmol. 1930;3(1):71–79. doi:10.1001/archopht.1930.00810030079004
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