While it cannot be said that the long debate over the pathogenesis of glaucoma has been brought within sight of a satisfactory conclusion, recent investigation has at least revealed some important facts, without an understanding of which any solution would always have been impossible. This is especially true of the observations in three fields: the biochemistry of the aqueous and vitreous, the physiology of the ocular blood-vascular system, including the capillaries, and the observations of the normal and glaucomatous eye which newer means of observation, such as the gonioscope and the slit-lamp, have made possible. As Duke-Elder stated,1 it is undoubtedly true that different schools of investigation have tried to make their particular observations the whole basis of a theory of glaucoma, to the exclusion of other investigations, when each school may have elucidated factors of importance in the disease. Still, in a review
GIFFORD SR. THE PATHOGENESIS OF GLAUCOMA. Arch Ophthalmol. 1930;3(1):88–98. doi:10.1001/archopht.1930.00810030098006
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